GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs2028299 | 1 | rs7111 | chr15:90373873 | AP3S2 | chr15:90373832-90456222:- | -0.7 | -10.63 | 2.6E-23 | Type 2 diabetes |
| BLCA | cis | rs7112513 | 1 | rs7112513 | chr11:117037361 | PCSK7 | chr11:117075789-117102811:- | -0.39 | -5 | 8.81E-7 | Protein quantitative trait loci |
| BLCA | cis | rs3829251 | 1 | rs7114252 | chr11:71237606 | KRTAP5-10 | chr11:71276609-71277666:+ | 0.2 | 3.88 | 0.000123 | Vitamin D levels |
| BLCA | cis | rs7112513 | 1 | rs7114963 | chr11:116875983 | PCSK7 | chr11:117075789-117102811:- | -0.4 | -5.15 | 4.22E-7 | Protein quantitative trait loci |
| BLCA | cis | rs4237643 | 1 | rs7115737 | chr11:43681249 | HSD17B12 | chr11:43702143-43878160:+ | -0.44 | -7.23 | 2.69E-12 | Forced vital capacity |
| BLCA | cis | rs7927771 | 1 | rs7120333 | chr11:47817441 | C1QTNF4 | chr11:47611216-47615961:- | -0.3 | -5.61 | 3.9E-8 | Subjective well-being |
| BLCA | cis | rs7112513 | 1 | rs7121347 | chr11:116867209 | PCSK7 | chr11:117075789-117102811:- | -0.4 | -5.15 | 4.22E-7 | Protein quantitative trait loci |
| BLCA | cis | rs7112513 | 1 | rs7122944 | chr11:117034619 | PCSK7 | chr11:117075789-117102811:- | -0.41 | -5.13 | 4.63E-7 | Protein quantitative trait loci |
| BLCA | cis | rs7112513 | 1 | rs7123517 | chr11:117027755 | PCSK7 | chr11:117075789-117102811:- | -0.41 | -5.13 | 4.63E-7 | Protein quantitative trait loci |
| BLCA | cis | rs7112513 | 1 | rs7124741 | chr11:116752219 | PCSK7 | chr11:117075789-117102811:- | -0.45 | -5.61 | 3.94E-8 | Protein quantitative trait loci |
| BLCA | cis | rs3796352 | 1 | rs71299622 | chr3:52917038 | TMEM110 | chr3:52867139-52931547:- | 0.46 | 4.22 | 3.0E-5 | Immune reponse to smallpox (secreted IL-2) |
| BLCA | cis | rs7927997 | 1 | rs7130588 | chr11:76270683 | CAPN5 | chr11:76777992-76837196:+ | -0.16 | -3.92 | 0.000105 | Crohn's disease;Gut microbiota (functional units) |
| BLCA | cis | rs3829251 | 1 | rs7130829 | chr11:71237702 | KRTAP5-10 | chr11:71276609-71277666:+ | 0.2 | 3.86 | 0.000132 | Vitamin D levels |
| BLCA | cis | rs13053817 | 1 | rs71324766 | chr22:29839659 | NIPSNAP1 | chr22:29950800-29977144:- | 0.29 | 3.95 | 9.15E-5 | Carotid atherosclerosis in HIV infection |
| BLCA | cis | rs71327718 | 1 | rs71327718 | chr3:125592857 | ALG1L | chr3:125648118-125655882:- | -0.4 | -5.67 | 2.86E-8 | Metabolite levels (HVA/5-HIAA ratio) |